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  • Title: Liver exposure to xenobiotics: the aging factor and potentials for functional foods.
    Author: Marotta F, Lecroix P, Harada M, Masulair K, Safran P, Lorenzetti A, Ono-Nita SK, Marandola P.
    Journal: Rejuvenation Res; 2006; 9(2):338-41. PubMed ID: 16706665.
    Abstract:
    Hepatocytes isolated from 20- and 4-month Wistar rats and cultured with or without alpha-linolenic acid (LNA) were then added with nutraceutical YHK or sylibin before the test with iron or copper. Overall, YHK proved to be more effective than sylibin in Fe/Cu-induced peroxidative damage on normal and LNA-loaded hepatocytes (p < 0.05). YHK exerted a significant protection against DPPH radical-scavenging activity in the "old" group (p versus sylibin) and against lipophilic generators in both age groups (p < 0.05 versus sylibin). Both compounds were ineffective on age-related increase of surface-charge density. These preliminary data suggest that age per se enhances the vulnerability of hepatocytes to xenobiotics, whereas some safe nutraceuticals seem to exert significant protective effects.
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