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  • Title: Hepatic veno-occlusive disease due to tacrolimus in a single-lung transplant patient.
    Author: Shah S, Budev M, Blazey H, Fairbanks K, Mehta A.
    Journal: Eur Respir J; 2006 May; 27(5):1066-8. PubMed ID: 16707401.
    Abstract:
    Hepatic veno-occlusive disease is defined as nonthrombotic fibrous obliterative endophlebitis of small centrilobular hepatic venules. Clinically, patients present with elevated liver enzymes and a triad of jaundice, hepatomegaly and ascites. Although reported as a complication of other solid organ and stem cell transplantation, there have been no reported cases to date of veno-occlusive disease following lung transplantation. The present authors report a case of veno-occlusive disease following single-lung transplantation in a patient on a triple-drug immunosuppressive regimen composed of tacrolimus, mycophenolate mofetil and prednisone. The diagnosis was established by transjugular liver biopsy and by discontinuing tacrolimus; there was clinical regression of symptoms and serological return to baseline.
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