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  • Title: Convection-enhanced delivery of immunotoxins and radioisotopes for treatment of malignant gliomas.
    Author: Vandergrift WA, Patel SJ, Nicholas JS, Varma AK.
    Journal: Neurosurg Focus; 2006 Apr 15; 20(4):E13. PubMed ID: 16709018.
    Abstract:
    The treatment of malignant gliomas has advanced significantly in the past 15 years. The simultaneous development of new targeting agents and techniques to deliver these high-molecular-weight compounds has led to improved efficacy and promising results in Phase III trials. Convection-enhanced delivery (CED) of macromolecules has emerged as the leading delivery technique for the treatment of malignant gliomas. A summary of the basic principles of CED and a review of the current human trials of protein targeting agents are provided.
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