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  • Title: Interaction of citrus juices with felodipine and nifedipine.
    Author: Bailey DG, Spence JD, Munoz C, Arnold JM.
    Journal: Lancet; 1991 Feb 02; 337(8736):268-9. PubMed ID: 1671113.
    Abstract:
    Six men with borderline hypertension took felodipine 5 mg with water, grapefruit juice, or orange juice. The mean felodipine bioavailability with grapefruit juice was 284 (range 164-469)% of that with water. The dehydrofelodipine/felodipine AUC ratio was lower, diastolic blood pressure lower, and heart rate higher with grapefruit juice than with water. Vasodilatation-related side-effects were more frequent. Orange juice had no such effects. Six healthy men took nifedipine 10 mg with water or grapefruit juice; the bioavailability with grapefruit juice was 134 (108-169)% of that with water.
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