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  • Title: [Impact of the duration of untreated psychosis among patients with a first episode: a one year follow-up study].
    Author: Apiquián-Guitart R, Fresán-Orellana A, García-Anaya M, Lóyzaga-Mendoza C, Nicolini-Sánchez H.
    Journal: Gac Med Mex; 2006; 142(2):113-20. PubMed ID: 16711545.
    Abstract:
    BACKGROUND: The delay on the onset of specific treatment has several prognostic implications for psychotic patients. Duration of untreated psychosis (DUP) has been considered a prognostic variable. A longer DUP has been associated with a poor clinical outcome. OBJECTIVE: To determine the DUP in a sample of first-episode psychotic patients and its relationship with recovery and relapse on a one-year follow-up study. MATERIAL AND METHODS: A sample of 66 first-episode psychotic patients was recruited and divided according to their diagnoses in affective and non-affective psychoses. Diagnoses were obtained with SCAN and DUP was registered for each patient. A clinical assessment for psychotic and affective symptoms was performed using standardized instruments. RESULTS: All patient studied showed clinical improvement during follow-up. Patients with a longer DUP showed poorer psychosocial adjustment and lower recovery indexes. Treatment suspension was the main variable associated with relapse. CONCLUSIONS: DUP is an important prognostic variable. Early detection programs are required to decrease the period between illness onset, diagnosis and treatment in first-episode psychotic patients.
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