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  • Title: Ketamine enhances the expression of serine racemase and D-amino acid oxidase mRNAs in rat brain.
    Author: Takeyama K, Yoshikawa M, Oka T, Kawaguchi M, Suzuki T, Hashimoto A.
    Journal: Eur J Pharmacol; 2006 Jul 01; 540(1-3):82-6. PubMed ID: 16716293.
    Abstract:
    We have evaluated the effects of the acute administration of noncompetitive N-methyl-D-aspartate receptor antagonist, ketamine, on the expression of serine racemase and D-amino acid oxidase mRNAs in several brain areas of rats. The ketamine administration produced a dose-dependent and transient elevation in the levels of serine racemase and D-amino acid oxidase mRNAs in all the brain areas. These findings suggest that there is a relationship between the gene expression of the d-serine-related enzymes and the blockade of the N-methyl-D-aspartate receptors.
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