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  • Title: Reversible, activity-dependent targeting of profilin to neuronal nuclei.
    Author: Birbach A, Verkuyl JM, Matus A.
    Journal: Exp Cell Res; 2006 Jul 15; 312(12):2279-87. PubMed ID: 16716297.
    Abstract:
    The actin cytoskeleton in pyramidal neurons plays a major role in activity-dependent processes underlying neuronal plasticity. The small actin-binding protein profilin shows NMDA receptor-dependent accumulation in dendritic spines, which is correlated with suppression of actin dynamics and long-term stabilization of synaptic morphology. Here we show that following NMDA receptor activation profilin also accumulates in the nucleus of hippocampal neurons via a process involving rearrangement of the actin cytoskeleton. This simultaneous targeting to dendritic spines and the cell nucleus suggests a novel mechanism of neuronal plasticity in which profilin both tags activated synapses and influences nuclear events.
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