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  • Title: Selective inhibition of herpes simplex virus by 5-amino-2,5-dideoxy-5-iodouridine.
    Author: Cheng YC, Goz B, Neenan JP, Ward DC, Prusoff WH.
    Journal: J Virol; 1975 May; 15(5):1284-5. PubMed ID: 167186.
    Abstract:
    5-Amino-2,5-dideoxy-5-iodouridine, a nel thymidine analogue, is a potent inhibitor of herpes simplex virus type 1 replication. In contrast to most other nucleoside analogues which possess antiviral activity, 5-amino-2,5-dideoxy-5-iodouridine exhibits little, if any, cellular toxicity. Preliminary evidence suggests that 5-amino-2,5-dideoxy-5-iodouridine selectively inhibits viral-specific DNA synthesis.
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