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  • Title: Zebra mussel antifouling activity of the marine natural product aaptamine and analogs.
    Author: Diers JA, Bowling JJ, Duke SO, Wahyuono S, Kelly M, Hamann MT.
    Journal: Mar Biotechnol (NY); 2006; 8(4):366-72. PubMed ID: 16718618.
    Abstract:
    Several aaptamine derivatives were selected as potential zebra mussel (Dreissena polymorpha) antifoulants because of the noteworthy absence of fouling observed on Aaptos sponges. Sponges of the genus Aaptos collected in Manado, Indonesia consistently produce aaptamine-type alkaloids. To date, aaptamine and its derivatives have not been carefully evaluated for their antifoulant properties. Structure-activity relationship studies were conducted using several aaptamine derivatives in a zebra mussel antifouling assay. From these data, three analogs have shown significant antifouling activity against zebra mussel attachment. Aaptamine, isoaaptamine, and the demethylated aaptamine compounds used in the zebra mussel assay produced EC(50) values of 24.2, 11.6, and 18.6 microM, respectively. In addition, neither aaptamine nor isoaaptamine produced a phytotoxic response (as high as 300 microM) toward a nontarget organism, Lemna pausicostata, in a 7-day exposure. The use of these aaptamine derivatives from Aaptos sp. as potential environmentally benign antifouling alternatives to metal-based paints and preservatives is significant, not only as a possible control of fouling organisms, but also to highlight the ecological importance of these and similar biochemical defenses.
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