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  • Title: The impact of prophylactic antibiotics on postoperative infection complication in elective laparoscopic cholecystectomy: a prospective randomized study.
    Author: Chang WT, Lee KT, Chuang SC, Wang SN, Kuo KK, Chen JS, Sheen PC.
    Journal: Am J Surg; 2006 Jun; 191(6):721-5. PubMed ID: 16720138.
    Abstract:
    BACKGROUND: The aim of this prospective randomized study was to investigate the necessity and impact of prophylactic antibiotics on postoperative infection complications in elective laparoscopic cholecystectomy. METHODS: At the time of induction of anesthesia, group A patients (n = 141) received 1 g cefazolin, and group B patients (control; n = 136) received 10 mL isotonic sodium chloride solution. Patients' characteristics and general operative outcomes were compared and analyzed. RESULTS: The overall rate of infection was 1.1% for total 277 patients (0.7% for group A patients and 1.5% for group B patients). No significant difference in infection complications was found between these 2 groups. Also any risk factors contributing to infection complications could not be found. CONCLUSIONS: We do not recommend the use of prophylactic antibiotics in elective laparoscopic cholecystectomy because they will not decrease the already-low rate of postoperative infectious complications.
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