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  • Title: Topical calcipotriol treatment in advanced breast cancer.
    Author: Bower M, Colston KW, Stein RC, Hedley A, Gazet JC, Ford HT, Combes RC.
    Journal: Lancet; 1991 Mar 23; 337(8743):701-2. PubMed ID: 1672178.
    Abstract:
    19 patients with locally advanced or cutaneous metastatic breast cancer were treated with the topical vitamin D analogue calcipotriol 100 micrograms daily. 14 patients completed 6 weeks' treatment; 3 showed a 50% reduction in the bidimensional diameter of treated lesions and 1 other patient showed a minimal response. 2 patients became hypercalcaemic during treatment. In all patients who responded the tumours contained receptors for 1,25-dihydroxyvitamin D3, shown by immunocytochemistry.
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