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  • Title: Immunogenicity of Danish-SSI 1331 BCG vaccine in the UK: comparison with Glaxo-Evans 1077 BCG vaccine.
    Author: Gorak-Stolinska P, Weir RE, Floyd S, Lalor MK, Stenson S, Branson K, Blitz R, Luke S, Nazareth B, Ben-Smith A, Fine PE, Dockrell HM.
    Journal: Vaccine; 2006 Jul 17; 24(29-30):5726-33. PubMed ID: 16723176.
    Abstract:
    The immunogenicity and reactogenicity, in British schoolchildren, of the newly introduced Danish-SSI 1331 BCG vaccine was compared with that of the previously used Glaxo-Evans 1077 BCG vaccine. Interferon-gamma (IFN-gamma) response to M. tuberculosis purified protein derivative (M.tb PPD) in a 6-day whole blood assay and delayed type hypersensitivity (DTH) to tuberculin PPD were determined before and 1 year after receiving BCG or no vaccination. Scar size was measured 1 year after vaccination. There was no evidence of a difference in immunogenicity (IFN-gamma and DTH conversion rates) but evidence of lower reactogenicity (scar size) with Danish-SSI 1331 compared to Glaxo-Evans 1077 vaccines.
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