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  • Title: Increased blink rates in schizophrenics. Influences of neuroleptics and psychopathology.
    Author: Mackert A, Flechtner KM, Woyth C, Frick K.
    Journal: Schizophr Res; 1991; 4(1):41-7. PubMed ID: 1672606.
    Abstract:
    During a standardized visuomotor task, eye blinking, a possible parameter of central dopaminergic activity, was studied in 18 previously medicated and eight drug-naive schizophrenic in-patients in the acute state and during remission. Whereas schizophrenics executed the visuomotor task with the same precision as age- and sex-matched normal control subjects did, the mean blink rate was increased in both schizophrenic groups. During neuroleptic treatment, the mean blink rate was reduced only in the group of drug-naive patients, but not in the previously neuroleptic treated schizophrenics. This varying blinking activity is discussed with respect to the development of neuroleptic tolerance and influence of psychopathology.
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