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  • Title: P2-P4 macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease.
    Author: Arasappan A, Njoroge FG, Chen KX, Venkatraman S, Parekh TN, Gu H, Pichardo J, Butkiewicz N, Prongay A, Madison V, Girijavallabhan V.
    Journal: Bioorg Med Chem Lett; 2006 Aug 01; 16(15):3960-5. PubMed ID: 16730985.
    Abstract:
    Synthesis and HCV NS3 serine protease inhibitory activity of 4-hydroxyproline derived macrocyclic inhibitors and SAR around this macrocyclic core is described in this communication. X-ray structure of inhibitor 38 bound to the protease is discussed.
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