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  • Title: [Linkage analysis of the polymorphism at D17S1878 site with essential hypertension].
    Author: Fu LY, Zhao YY, Shi JP, Li H, Wang WL, Lu JY, Liu H.
    Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2006 Apr; 28(2):129-33. PubMed ID: 16733890.
    Abstract:
    OBJECTIVE: To explore the linkage of the polymorphism at D17S1878 site with susceptible gene of essential hypertension. METHODS: Forty-five pedigrees from the high prevalence region of the hypertension were collected. The polymorphism of D17S1878 site was genotyped with genetic analyzer and gene-scan software. Discordant sib pair analysis and affected sib pair analysis were used in linkage analysis. RESULTS: There were significant differences in the age, male, alcohol-consuming, over-salt intake, average systolic pressure, average diastolic pressure, waist-to-hip-ratio, total cholesterol, high-density lipoprotein, and low density lipoprotein between the hypertensive sib and the normotensive sib (P < 0.05). There were eleven alleles at D17S1878 site, and the allele frequency was significantly different between the hypertensive and normotensive sibs (P < 0.05). Forty-three pedigrees were analyzed with affected sib pair analysis (t = 3.05, P < 0.05). CONCLUSION: The polymorphism of D17S1878 may be linked with susceptible genes of essential hypertension.
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