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Title: ['Migraine and a hole in the heart': causal relationship between migraine and patent foramen ovale not established]. Author: Terwindt GM, Haan J, Bax JJ, de Bruijn SF, Ferrari MD. Journal: Ned Tijdschr Geneeskd; 2006 May 13; 150(19):1050-2. PubMed ID: 16733978. Abstract: The relationship between patent foramen ovale (PFO) and migraine is controversial. A common genetic background seems possible, but there is no evidence for a causal relationship. Despite the lack of evidence, PFO closure is recommended in many countries as a remedy for migraine. At present, PFO closure for migraine should only be carried out under strictly controlled clinical trial conditions.[Abstract] [Full Text] [Related] [New Search]