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  • Title: Difference in susceptibility to activity-based anorexia in two inbred strains of mice.
    Author: Gelegen C, Collier DA, Campbell IC, Oppelaar H, van den Heuvel J, Adan RA, Kas MJ.
    Journal: Eur Neuropsychopharmacol; 2007 Feb; 17(3):199-205. PubMed ID: 16735105.
    Abstract:
    Food restricted rodents develop activity-based anorexia in the presence of a running wheel, characterised by increased physical activity, weight loss and decreased leptin levels. Here, we determined trait differences in the development of activity-based anorexia between C57BL/6J and DBA/2J inbred mouse lines previously reported as having low and high anxiety, respectively. C57BL/6J mice housed with running wheels and exposed to scheduled feeding reduced their wheel activity, in contrast to DBA/2J mice which exhibited increased behavioural activity under these conditions. Food restriction induced hypoleptinemia in both strains, but the decline in plasma leptin was stronger in DBA/2J mice and correlated with increased activity only in that strain. These data suggest that plasma leptin level dynamics rather than hypoleptinemia alone influences the development of activity-based anorexia and that recombinant inbred panels based on these progenitor lines offer opportunities for the identification of molecular determinants for anorexia nervosa related behavioural traits.
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