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  • Title: Palytoxin: a potent stimulator of catecholamine release from cultured bovine adrenal chromaffin cells.
    Author: Nakanishi A, Yoshizumi M, Morita K, Murakumo Y, Houchi H, Oka M.
    Journal: Neurosci Lett; 1991 Jan 02; 121(1-2):163-5. PubMed ID: 1673546.
    Abstract:
    The effect of palytoxin (PTX), a potent marine toxin, on catecholamine release from cultured bovine adrenal chromaffin cells was examined. PTX at concentrations of over 10(-9) M induced catecholamine release dose-dependently. About 40-50% of the total cellular catecholamine was released during 20-min incubation with 3 x 10(-8) M PTX. PTX-induced catecholamine release was dependent on both extracellular Na+ and Ca2+, and was inhibited by organic and inorganic Ca2+ channel blockers, but not by tetrodotoxin. PTX-induced increase in 45Ca2+ influx into the cells, which was associated with catecholamine release, was also inhibited by these Ca2+ channel blockers. These results indicated that PTX-induced catecholamine release was mediated by activation of Na(+)-dependent, tetrodotoxin (TTX) insensitive voltage-dependent Ca2+ channels.
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