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  • Title: [Expression of Nestin, CK19, insulin, glucagon and somatostatin in embryonic pancreas].
    Author: Yan KM, Li AD, Yang HJ, Mei Y, Zhou HY.
    Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2005 May; 21(3):353-5. PubMed ID: 16736556.
    Abstract:
    AIM: To investigate the expression of Nestin, CK19, insulin, glucagon and somatostatin in the development of embryonic pancreas. METHOD: Sample collection was conducted in accordance to the principle of informed consent. Immunohistochemical SABC method and LAB-SA for double satining were used to study the expression of the molecules in human embryonic pancreas. RESULTS: (1) There are few nestin-positive cells in the stroma of the embryonic pancreas. CK19 is consistently expressed in the epithelial cells of pancreatic ducts. (2) From 7 weeks of gestation, pancreatic duct epithelial cells begin to differentiate into insulin, glucagon and somatostatin-positive cells. CONCLUSION: Nestin-positive pancrease stem cells are in the stroma of human embryonic pancrease. Pancreatic duct epithelial cells differentiate into islet cells secreting insulin at the early stage of embryonic development.
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