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  • Title: New coupling reaction of secondary amines, aldehydes, and alkynes catalyzed by an iridium complex.
    Author: Sakaguchi S, Mizuta T, Ishii Y.
    Journal: Org Lett; 2006 Jun 08; 8(12):2459-62. PubMed ID: 16737288.
    Abstract:
    A new reductive coupling reaction of secondary amines, aldehydes, and alkynes using an iridium complex as catalyst has been developed. For example, dibutylamine was allowed to react with butyraldehyde and 1-octyne in 1,4-dioxane at 50 degrees C under the influence of a catalytic amount of [IrCl(cod)](2) to give the corresponding allylamines such as N,N-dibutyl-2-butylideneoctylamine and N,N-2-tributyl-2-octenylamine in excellent yields. [reaction: see text]
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