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  • Title: N,N-dimethyl-beta-alanine as an inexpensive and efficient ligand for palladium-catalyzed Heck reaction.
    Author: Cui X, Li Z, Tao CZ, Xu Y, Li J, Liu L, Guo QX.
    Journal: Org Lett; 2006 Jun 08; 8(12):2467-70. PubMed ID: 16737290.
    Abstract:
    N,N-Dimethyl-beta-alanine was found to be a more powerful phosphine-free ligand than the previously reported ligand, N,N-dimethylglycine, in the Pd-catalyzed Heck reaction for a variety of aryl bromides, aryl iodides, and activated aryl chlorides with a practical turnover number of 10(3). Both kinetic and theoretical studies suggested that N,N-dimethyl-beta-alanine led to faster oxidative addition of an aryl halide to Pd than N,N-dimethylglycine. [reaction: see text]
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