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  • Title: Ambient humidity influences the rate of skin barrier maturation in extremely preterm infants.
    Author: Agren J, Sjörs G, Sedin G.
    Journal: J Pediatr; 2006 May; 148(5):613-7. PubMed ID: 16737871.
    Abstract:
    OBJECTIVES: To test the hypothesis that the level of relative humidity (RH) in which preterm infants are nursed might influence their postnatal skin maturation. STUDY DESIGN: In 22 preterm infants (GA 23-27 weeks), transepidermal water loss (TEWL) was determined at postnatal ages (PNA) of 0, 3, 7, 14, and 28 days. At a PNA of 7 days, the infants were randomized to care at either 50% or 75% RH. RESULTS: TEWL decreased at a slower rate in infants nursed at the higher RH. At a PNA of 28 days, TEWL was about twice as high in infants nursed at 75% RH (22 +/- 2 g/m2 h) than in those nursed at 50% RH (13 +/- 1 g/m2 h; P < .001). CONCLUSIONS: The results indicate that the level of RH influences skin barrier development, with more rapid barrier formation in infants nursed at a lower RH. The findings have an impact on strategies for promoting skin barrier integrity in extremely preterm infants.
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