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  • Title: [The role of prostaglandins in the effect of beta-blockers on stimulated blood platelets].
    Author: Nosál' R, Jancinová V, Petríková M.
    Journal: Vnitr Lek; 1991 Mar; 37(3):261-7. PubMed ID: 1674390.
    Abstract:
    Atenolol, a selective beta-blocker, slightly potentiates the stimulated aggregation of platelets against dose-dependence. The drug potentiates similarly stimulated release of arachidonic acid, it does not influence the formation of malondialdehyde and the thromboxane B2 production in stimulated platelets. The non-selective beta-blocker propranolol inhibits in a dose-dependent way stimulated aggregation, the release of arachidonic acid, it reduces thromboxane B2 production in stimulated platelets. The authors revealed that the anti-aggregating action of beta-blockers is closely related to their ability to influence prostaglandin synthesis in stimulated platelets.
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