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  • Title: Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation.
    Author: Margolin Y, Cloutier JF, Shafirovich V, Geacintov NE, Dedon PC.
    Journal: Nat Chem Biol; 2006 Jul; 2(7):365-6. PubMed ID: 16751762.
    Abstract:
    Guanine in DNA is a major oxidation target owing to its low ionization potential (IP), and there is often an inverse correlation between damage frequency and sequence-dependent variation in guanine IP. We report that the biological oxidant nitrosoperoxycarbonate (ONOOCO2(-)) paradoxically selects guanines with the highest IP in GC-containing contexts. Along with sequence-dependent variation in damage chemistry, this behavior points to factors other than charge migration as determinants of genomic DNA oxidation.
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