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  • Title: Alcohol exposure during adolescence impairs auditory fear conditioning in adult Long-Evans rats.
    Author: Bergstrom HC, McDonald CG, Smith RF.
    Journal: Physiol Behav; 2006 Jul 30; 88(4-5):466-72. PubMed ID: 16753191.
    Abstract:
    Few studies have examined long-term effects of ethanol on auditory fear conditioning, and fewer still have examined whether adolescence represents a unique period of vulnerability. We investigated the impact of ethanol consumption during adolescence and adulthood on fear conditioning, following an extended abstinence period. Male and female Long-Evans rats (N = 80) consumed 10% ethanol or water (control) in a limited-access drinking paradigm (1 h) between postnatal (P) days 28-45 (adolescent) and P80-97 (adult). After the abstinence period (30 days), ethanol and control groups were assessed on the auditory fear-conditioning task. Alcohol consumption impaired tone conditioning in the male and female adolescent group. There were no persisting effects of adult dosing. In addition, adolescent rats consumed more ethanol than adults. These data provide evidence that ethanol consumption during adolescence produces enduring effects on auditory fear conditioning. The age-specific effect of ethanol may be attributable to an interplay of higher ethanol intake and the unique neurobiological characteristics of adolescents.
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