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  • Title: Manoalide derivatives from a sponge, Luffariella sp.
    Author: Zhou GX, Molinski TF.
    Journal: J Asian Nat Prod Res; 2006; 8(1-2):15-20. PubMed ID: 16753777.
    Abstract:
    A new derivative of manoalide, 24-n-propyl-O-manoalide (1) together with manoalide (4) and four known derivatives (2, 3, 5, 6) were isolated from the methanolic extract of a sponge. Their structures were elucidated on the basis of spectroscopic method. All the compounds showed significant cytotoxicity against HCT-116 cell line by MTS assay. Secomanoalide indicated antifungal activity on fungal lines Candida glabrata,Candida krusei and Candida albicans by invitro antibiotic assay.
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