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  • Title: Four new neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities.
    Author: Dai SJ, Chen M, Liu K, Jiang YT, Shen L.
    Journal: Chem Pharm Bull (Tokyo); 2006 Jun; 54(6):869-72. PubMed ID: 16755060.
    Abstract:
    Four new neo-clerodane diterpenoid alkaloids, named scutebarbatines C-F (1-4), were isolated from the whole plants of Scutellaria barbata D. DON. Their structures were elucidated by spectral analyses (UV, IR, FAB-MS, 1D-NMR and 2D-NMR). In vitro, compounds 1-4 showed significant cytotoxic activities against three human cancer cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and gave IC(50) values in the range 3.9-7.8 muM.
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