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  • Title: Synthesis and biological activity of [[(heterocycloamino)alkoxy] benzyl]-2,4-thiazolidinediones as PPARgamma agonists.
    Author: Jeon R, Kim YJ, Cheon Y, Ryu JH.
    Journal: Arch Pharm Res; 2006 May; 29(5):394-9. PubMed ID: 16756084.
    Abstract:
    Benzothiazole derivatives of thiazolidinediones (TZD) were synthesized using a modified Mitsunobu reaction of 2-(benzothiazol-2-ylmethylamino)ethanol (2) with 5-(4-hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione and assayed for activity on peroxisome proliferator-activated receptor (PPAR) subtypes and inhibitory activity of NO production in lipopolysaccharide-activated macrophages. Most of the tested compounds were identified as potent PPARgamma agonists, indicating their potential as drug candidates for diabetes.
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