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  • Title: [The antioxidative-prooxidative balance in children with asthma treated with inhaled corticosteroids and long acting beta2-agonists].
    Author: Szlagatys-Sidorkiewicz A, Korzon M, Małaczyńska T, Renkel J, Popadiuk S, Woźniak M.
    Journal: Pneumonol Alergol Pol; 2005; 73(2):178-81. PubMed ID: 16756149.
    Abstract:
    UNLABELLED: The aim of study was to analyze the effect of treatment with inhaled corticosteroids and long acting beta2-agonists on antioxidative-prooxidative balance in children with asthma. MATERIALS AND METHODS: Twenty children with newly diagnosed asthma before treatment (group 1), fourteen children with diagnosed asthma treated with inhaled corticosteroids and long acting beta2-agonists and 57 healthy children were ioncluded in the study. In all cases plasma protein carbonyls and activity of erythrocyte SOD was assayed. RESULTS: Plasma protein carbonyls in both group I (1,01 nmol/g of protein, SD=0,30) and group II (0,94; SD=0,15) was significantly higher than in group III (0,85; SD=0,24) (I vs III p<0,033; II vs III p<0,031). The highest SOD activity was found in group II (3156,4 U/gHb; SD=976,1) (II vs I p<0,02; II vs III p<0,0001). SOD activity n group I (2435,8, SD=730,2) was higher than in group III (1533,1, SD=703,8) (p<0,0001). CONCLUSIONS: The increase in SOD activity in children with asthma seems to be a response to intensification of oxidative stress. Treatment of asthma with inhaled corticosteroids and long acting beta2-agonists augments antioxidative defense by increase in superoxide dismutase activity.
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