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  • Title: Lysenin forms a voltage-dependent channel in artificial lipid bilayer membranes.
    Author: Ide T, Aoki T, Takeuchi Y, Yanagida T.
    Journal: Biochem Biophys Res Commun; 2006 Jul 21; 346(1):288-92. PubMed ID: 16756950.
    Abstract:
    Lysenin, a hemolytic protein derived from the body fluid of earthworm, was incorporated into artificial bilayer membranes. Upon insertion, it formed a voltage-dependent large conductance channel in asolectin bilayers in a sphingomyelin-dependent manner. The channel had low ion-selectivity. Single-channel conductance was calculated as approximately 550 pS in 100 mM KCl. The channel in asolectin bilayers closed when the membrane was held at a positive potential. In contrast, the channel showed no voltage dependency in membranes made of pure phosphatidylcholine and sphingomyelin, suggesting some lipid contents included in the asolectin membranes affected channel gating.
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