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  • Title: Mechanisms of hepatoprotective effect of preparation containing superlow doses of antibodies to granulocytic colony-stimulating factor.
    Author: Epstein OI, Zyuz'kov GN, Sotnikova NV, Stavrova LA, Fomina TI, Vetoshkina TV, Sergeeva SA, Dubskaya TY, Dygai AM, Gol'dberg ED.
    Journal: Bull Exp Biol Med; 2005 Nov; 140(5):598-602. PubMed ID: 16758635.
    Abstract:
    The hepatoprotective effects of superlow dose preparation of antibodies to granulocytic CSF were studied on a model of CCl4-induced hepatitis. The preparation exhibited high antiinflammatory and antisclerotic activities determined by stimulation, mobilization, and determined homing of mesenchymal stem cells into damaged liver with subsequent differentiation of these cells into mature hepatocytes.
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