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  • Title: Hemopoietic precursors: mechanisms of regulation under conditions of chronic stress.
    Author: Sherstoboev EY, Minakova MY.
    Journal: Bull Exp Biol Med; 2005 Nov; 140(5):616-20. PubMed ID: 16758639.
    Abstract:
    We studied the content of hemopoietic precursor cells in the bone marrow, production of IL-1, IL-3, and colony-stimulating and erythropoietic activities by bone marrow cells under conditions of chronic stress. It was shown that in mice subjected to 15-h immobilization no hyperplasia of the bone marrow developed against the background of increased content of committed erythro- and granulomonocytopoietic precursors and enhanced production of short-distant humoral regulators of hemopoiesis, which reflects dysregulation of hemopoietic cells proliferation and differentiation processes in stressed animals.
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