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  • Title: Function of hemopoietic stem cells under conditions of cytostatic myelosuppression and treatment with hemostimilators.
    Author: Zhdanov VV, Gur'yantseva LA, Udut EV, Khrichkova TY, Simanina EV, Gol'dberg VE.
    Journal: Bull Exp Biol Med; 2005 Nov; 140(5):631-4. PubMed ID: 16758642.
    Abstract:
    We compared the function of hemopoietic stem cells under conditions of cytostatic myelosuppression (cyclophosphamide treatment) and during treatment with granulocytopoiesis stimulators. It was found that unipotent hemopoietic precursor cells are most sensitive to cyclophosphamide. Different effects of hemostimulators on stem cells are determined by different proportions between proliferation and differentiation processes.
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