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  • Title: Mechanisms of the effects of granulocytic CSF on tissue reparation during chronic CCl4-induced damage to the liver.
    Author: Sotnikova NV, Stavrova LA, Gur'antseva LA, Khrichkova TY, Fomina TI, Vetoshkina NV, Dubskaya TY, Sergeeva SA, Epshtein OI, Ermolaeva LA, Dygai AM, Gol'dberg ED.
    Journal: Bull Exp Biol Med; 2005 Nov; 140(5):644-7. PubMed ID: 16758645.
    Abstract:
    Hepatoprotective effects of granulocytic CSF were studied using experimental model of CCl4-induced hepatitis. It was found that treatment with granulocytic CSF increased the content of stromal precursors and mesenchymal stem cells in the bone marrow and peripheral blood with subsequent increase in the number of hepatic precursor cells in the liver. These findings attest to mobilization of progenitor mesenchymal cells and their migration into damages liver tissue, which accelerates its regeneration related to changes in the parenchyma, but not connective tissue development.
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