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  • Title: A high-performance liquid chromatography method for hypoxanthine determination in vitreous humour: application to estimation of post mortem interval.
    Author: Muñoz JI, Costas E, Rodríguez-Calvo MS, Suárez-Peñaranda JM, López-Rivadulla M, Concheiro L.
    Journal: Hum Exp Toxicol; 2006 May; 25(5):279-81. PubMed ID: 16758771.
    Abstract:
    We have developed a new technique to determine the concentration of hypoxanthine [Hx] in a reverse phase column using a modified high-performance liquid chromatography (HPLC) method that is faster and more reliable than those previously described. In this paper we present a formula for estimating the post mortem interval (PMI) based on this HPLC method by applying the inverse prediction method. The regression line obtained by changing the variables gives PMI = 0.183 [Hx] + 0.599 (PMI in hours, [Hx] in micromol/L, R2 = 0.531, P < 0.05).
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