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  • Title: Healthy centenarian subjects: the effect of red wine consumption on liver function tests.
    Author: Pinzani P, Petruzzi E, Orlando C, Malentacchi F, Petruzzi I, Pazzagli M, Masotti G.
    Journal: J Endocrinol Invest; 2005; 28(11 Suppl Proceedings):120-2. PubMed ID: 16760640.
    Abstract:
    Liver function is well maintained with increasing age. The aim of our study was to investigate if long-term moderate (<or=500 ml/day) red wine consumption influences the most common laboratory tests of liver function in healthy centenarians. Wine consumption habits were classified as moderate red wine drinkers (D) (<or=500 ml/day of red wine consumption in the past and present) (no.=3 males, 16 females) and abstainers (A) who never consumed red wine or alcoholic beverages (no.=1 male, 4 females). None were heavy drinkers. Laboratory tests revealed low levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). AST was higher in A (Mean+/-SE=8.40+/-0.32 U/l) in comparison to D (Mean+/-SE=6.25+/-0.72 U/l), but this difference was not statistically significant. Total-bilirubin (Tbil), alkaline phosphatase (AlkP), gamma- glutamyltransferase (GGT) and pseudocholinesterase (CHE) were in the normal range, and there was no difference between D and A. We conclude that red wine consumption in centenarians had no negative effect on circulating liver enzyme activities.
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