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  • Title: Intestinal necrosis in a patient with rheumatoid arthritis receiving anti-TNF treatment.
    Author: Ruppert M, De Clerck L, van Offel J, Hubens G, Balliu L, Vaneerdeweg W.
    Journal: Acta Chir Belg; 2006; 106(2):225-7. PubMed ID: 16761484.
    Abstract:
    Vasculitis leading to intestinal necrosis is a rare complication of rheumatoid arthritis. The introduction of anti-TNF treatment for methotrexate-resistant cases improved disease-control substantially in these often more aggresive forms of rheumatoid arthritis. As far as we know only two cases of severe vasculitis following anti-TNF treatment have been reported. We describe a 45-year old female patient with severe rheumatoid arthritis, who presented with an epileptic insult, renal failure and a quickly deteriorating general condition due to intestinal vasculitis, while she had been receiving anti-TNF treatment for 6 months.
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