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  • Title: Towards a molecular understanding of T-cell differentiation.
    Author: Clevers HC, Owen MJ.
    Journal: Immunol Today; 1991 Feb; 12(2):86-92. PubMed ID: 1676267.
    Abstract:
    Lymphoid differentiation is one of the best studied examples of mammalian development. Here Hans Clevers and Michael Owen describe how the cloning of the genes that encode T-cell-specific membrane proteins allows the identification of transcription factors that control the expression of these T-cell genes. Such transcription factors play a key role in the development of the mature T-cell phenotype by functioning as 'master regulators of T-cell differentiation'.
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