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  • Title: Serum homocysteine and long-term risk of myocardial infarction and sudden death in patients with coronary heart disease.
    Author: Haim M, Tanne D, Goldbourt U, Doolman R, Boyko V, Brunner D, Sela BA, Behar S.
    Journal: Cardiology; 2007; 107(1):52-6. PubMed ID: 16763372.
    Abstract:
    We have prospectively evaluated the risk of incident coronary events in association with serum total homocysteine in patients with preexisting chronic coronary heart disease. A nested case-control design was used. Total homocysteine concentration was measured in baseline fasting serum samples from patients with chronic coronary heart disease enrolled in the Bezafibrate Infarction Prevention Study (n = 3,090) who developed coronary events during 6.2 years of follow-up (n = 69). They were matched for age and gender with controls without subsequent cardiovascular events. Elevated homocysteine levels were associated with 2.5 times higher risk of subsequent coronary events and each 5 mumol/l increment was associated with a 25% higher risk.
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