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  • Title: Wnt/PCP signaling: a veritable polar star in establishing patterns of polarity in embryonic tissues.
    Author: Barrow JR.
    Journal: Semin Cell Dev Biol; 2006 Apr; 17(2):185-93. PubMed ID: 16765615.
    Abstract:
    Embryonic patterning has traditionally been viewed as the establishment of spatially significant gene expression in response to secreted signals. Recent work has highlighted the role of the Wnt/planar cell polarity (PCP) pathway in patterning tissues. Rather than establishing characteristic arrays of gene expression, however, this pathway functions to institute uniform polarity of cells within a tissue. Cells thus polarized can undergo directed migrations, cell divisions, etc., which are essential for normal morphogenesis. In this review, I will highlight the similarities between mechanisms that establish patterns of polarity between Drosophila and vertebrates. Further, I will discuss recent advances with regard to Wnt/PCP signaling in vertebrates.
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