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  • Title: [An investigation for genetic polymorphisms of 10 STR loci on chromosome X of Chinese Hui nationality population in Ningxia region of China].
    Author: Feng X, Xu P, Tuo Y, Yu B, Li SB.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2006 Jun; 23(3):346-8. PubMed ID: 16767682.
    Abstract:
    OBJECTIVE: To investigate the alleles and genotypes frequency of 10 short tandem repeat (STR) loci (DXS101, DXS6789, DXS6799, DXS6804, DXS7130, DXS7132, DXS7133, DXS7423, HPRTB, DXS8378) on X chromosome of Chinese Hui nationality population. METHODS: The study of 10 STR loci was performed by using the techniques of PCR, polyacylamide gel electrophoresis and silver staining. RESULTS: Among unrelated Hui individuals, the allele numbers of 10 STR loci DXS101, DXS6789, DXS6799, DXS6804, DXS7130, DXS7132, DXS7133, DXS7423, HPRTB, DXS8378 were 9, 8, 4, 6, 6, 6, 4, 4, 5 or 5 respectively; the numbers of genotypes were 17, 22, 7, 14, 14, 15, 6, 7, 12 or 8 respectively. The distribution of genotypes from these 10 STR systems fitted the Hardy-Weinberg equilibrium (P> 0.05). Polymorphisms information content of 10 STR loci, except for DXS7133 (0.48) and DXS7423 (0.48), ranged from 0.54 (DXS6799) to 0.80 (DXS6789); the power of discrimination were from 0.89 (DXS7133, DXS7423) to 0.99 (DXS6789, DXS7132, DXS101). CONCLUSION: The loci of 10 STR on chromosome X are appropriate for individual identification, paternity testing involving a female child and for study on related disease.
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