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  • Title: The role of surface charging during the coadsorption of mercaptohexanol to DNA layers on gold: direct observation of desorption and layer reorientation.
    Author: Arinaga K, Rant U, Tornow M, Fujita S, Abstreiter G, Yokoyama N.
    Journal: Langmuir; 2006 Jun 20; 22(13):5560-2. PubMed ID: 16768474.
    Abstract:
    We study the coadsorption of mercaptohexanol onto preimmobilized oligonucleotide layers on gold. Monitoring the position of the DNA relative to the surface by optical means directly shows the mercaptohexanol-induced desorption of DNA and the reorientation of surface-tethered strands in situ and in real time. By simultaneously recording the electrochemical electrode potential, we are able to demonstrate that changes in the layer conformation are predominantly of electrostatic origin and can be reversed by applying external bias to the substrate.
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