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  • Title: The effects of deoxycorticosterone-induced sodium appetite on hedonic behaviors in the rat.
    Author: Morris MJ, Na ES, Grippo AJ, Johnson AK.
    Journal: Behav Neurosci; 2006 Jun; 120(3):571-9. PubMed ID: 16768609.
    Abstract:
    The authors tested the hypothesis that chronic treatment with a dose of deoxycorticosterone acetate (DOCA) known to elicit a robust sodium appetite can negatively affect the hedonic state of rats. Daily treatment with DOCA with no opportunity to ingest saline produced a rightward shift in the midpoint (effective current 50) of lateral hypothalamic self-stimulation (LHSS) current-response functions and reduced intakes of a palatable sucrose solution. Providing rats with 0.3 M saline during DOCA treatment prevented the rightward shift in LHSS response functions and the decrease in sucrose intake. The authors concluded that a chronic sodium appetite, with no opportunity to attenuate the appetite, can elicit a reduced responsiveness to reward.
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