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  • Title: Plasma atrial natriuretic factor and catecholamines before and during excision of pheochromocytoma.
    Author: Donckier JE, Michel LA, Collard E, Galanti L, Harvengt C, Berbinschi A, Ketelslegers JM, Buysschaert M.
    Journal: Acta Chir Belg; 1991; 91(2):112-6. PubMed ID: 1676862.
    Abstract:
    We studied changes of atrial natriuretic factor (ANF) and catecholamines in three patients with pheochromocytoma occurring in the familial syndrome of multiple endocrine neoplasia type IIa. Previous studies have suggested a stimulating effect of catecholamines on ANF release. In pheochromocytoma, we observed normal basal ANF levels despite increased catecholamine secretion. In contrast, a rise in plasma ANF was observed when a hypertensive paroxysm occurred. Also during surgery, dissection of pheochromocytoma led to a rise in plasma ANF and catecholamines associated with an increase in blood pressure (in the 3 cases) and in pulmonary artery pressure (in 2 cases). We concluded that chronic elevation of basal catecholamines are without effect on plasma ANF but that manipulation of pheochromocytoma leads to a stimulation of ANF release, possibly mediated by either a direct effect of endogenously released catecholamines and/or an increase in atrial pressure.
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