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  • Title: Rapid infusion of cold saline (4 degrees C) as adjunctive treatment of fever in patients with brain injury.
    Author: Badjatia N, Bodock M, Guanci M, Rordorf GA.
    Journal: Neurology; 2006 Jun 13; 66(11):1739-41. PubMed ID: 16769952.
    Abstract:
    The use of rapid infusion of large-volume cold saline (CS) as an adjunctive therapy for treating refractory fever in nine patients is reported. A decline in temperature (39.2 +/- 0.3 vs 37.1 +/- 1.2 degrees C, p = 0.006) at 2 hours and fever burden (97.3 +/- 343.8 vs 734.3 +/- 422.3 degrees C*min, p = 0.02) at 12 hours was noted after CS bolus. Rapid infusion of large-volume CS may be used as an adjunct for inducing normothermia in refractory febrile patients.
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