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  • Title: Viral nanoparticles donning a paramagnetic coat: conjugation of MRI contrast agents to the MS2 capsid.
    Author: Anderson EA, Isaacman S, Peabody DS, Wang EY, Canary JW, Kirshenbaum K.
    Journal: Nano Lett; 2006 Jun; 6(6):1160-4. PubMed ID: 16771573.
    Abstract:
    A nanoparticle magnetic resonance imaging (MRI) contrast agent was developed by conjugation of more than 500 gadolinium chelate groups onto a viral capsid. The high density of paramagnetic centers and slow tumbling rate of modified MS2 capsids provided enhanced T1 relaxivities up to 7200 mM-1s-1 per particle. A bimodal imaging agent was generated by sequential conjugation of fluorescein and Gd3+ chelate. These results illustrate the potential for engineering natural protein assemblies to address bionanotechnology applications.
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