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  • Title: [Mechanism of the action of apressin under conditions of high temperature and physical exertion].
    Author: Denisenko PP, Poliakova MA.
    Journal: Farmakol Toksikol; 1976; 39(3):290-3. PubMed ID: 16774.
    Abstract:
    In experiments on rats subject to study were regularities governing the metabolism of glycogen, milk, pyruvic acid, phosphocreatine in the liver tissues, cortex, musculus gastrocnemius and in the myocardium, as well as of acids in the peripheral blood at 40 degrees C of outside temperature, 95 per cent humidity and during swimming. Investigations also covered preventive application of apressin in rats. The influence of stress was found to produce metabolic changes in the organism of rats. In hypoxia apressin tended to prolong the life-span of the test animals by as much as 30 per cent, to keep intact metabolism in the musculus gastrocnemius and in the myocardium, but, when used in a dose of 0.05 mg/kg, it failed to avert disorders in the cortex tissues.
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