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  • Title: Palladium-catalyzed intramolecular cyanoamidation of alkynyl and alkenyl cyanoformamides.
    Author: Kobayashi Y, Kamisaki H, Yanada R, Takemoto Y.
    Journal: Org Lett; 2006 Jun 22; 8(13):2711-3. PubMed ID: 16774238.
    Abstract:
    [reaction: see text] The five- to seven-membered alpha-alkylidene lactams were prepared in 45-99% yield by the palladium-catalyzed cyanoamidation of alkynyl cyanoformamides. The reaction proceeded exclusively in a 5-exo mode, giving the corresponding (Z)-alkenes as major products. The reaction was also applied to 1,1-disubstituted alkenes to afford oxindoles bearing a quaternary carbon center.
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