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  • Title: Specific metabolic pathway in vitro of pinazepam and diazepam by liver microsomal enzymes of different animal species.
    Author: Comi V, Fossati A, Gervasi GB.
    Journal: Farmaco Sci; 1977 Apr; 32(4):278-85. PubMed ID: 16776.
    Abstract:
    The metabolic pathway of Pinazepam and Diazepam in vitro was studied with rat, guinea pig and dog liver microsomes using a chromatographic and spectrophotometric technique. Two main pathways were observed, N1-dealkylation and C3-hydroxylation. N1-dealkylation was shown to be the predominant reaction for Pinazepam in all the animal species studied, while C3-hydroxylation was the major metabolic pathway for Diazepam in the rat. No oxazepam was found when Pinazepam and Diazepam were incubated with liver microsomes.
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