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  • Title: Bisphosphonate-induced osteonecrosis of the jaws: a case report and literature review.
    Author: Tsai WS, Haghighi K, Placa SJ.
    Journal: Gen Dent; 2006; 54(3):215-9; quiz 220-2. PubMed ID: 16776417.
    Abstract:
    Bisphosphonates are nonmetabolized analogues of pyrophosphate that are used for treating skeletal complications secondary to bone metastases. These drugs are capable of localizing to bone and inhibiting osteoclastic activity; however, their exact mechanisms of action remain unclear. Recently, it has been documented that administration of bisphosphonates has been associated with osteonecrosis of the jaws. This article details the case of a woman who received intravenous administration of bisphosphonate for metastatic breast cancer and subsequently developed osteonecrosis in both the maxillary and mandibular jaws.
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